The Lean Physique stack is a powerful and synergistic protocol designed for advanced users during a caloric deficit. Its primary goals are to preserve (or even build) lean muscle, drastically increase fat loss, and enhance endurance and recovery while cutting.
It combines the potent anabolic agent RAD-140 for muscle retention, the restorative MK-2866 for joint health and protein synthesis, and the powerful metabolic modulator GW-501516 for fat oxidation and stamina.
The Lean Physique SARMs Stack includes:
- NEO SARMs Testolone (RAD-140) — 10 mg / 50 tablets ×1
- NEO SARMs Ostarine (MK-2866) — 10 mg / 50 tablets ×1
- NEO SARMs Cardarine (GW-501516) — 10 mg / 50 tablets ×1
- Novo-Pharm Nolvadex — 20 mg / 30 tabs ×1
Each compound plays a specific, non-redundant role—anchoring muscle, supporting recovery, and driving endurance and fat oxidation. To ensure proper recovery after suppression, this bundle includes a FREE PCT component.
What’s in the Stack
Anabolic Anchor (RAD-140)
Provides a strong androgenic base to prevent muscle catabolism in a deficit, promoting hard, dense muscle and significant strength retention. It is the primary driver of suppression in this stack.
Healing & Synthesis Agent (MK-2866)
Supports muscle protein synthesis, enhances nitrogen retention, and provides notable benefits to joint healing and tendon strength—crucial when training hard in a deficit.
Metabolic Engine (GW-501516 – Cardarine)
NOT a SARM, but a PPARδ agonist. It dramatically improves endurance, increases fatty acid oxidation, and improves lipid profiles (raises HDL). Crucially, it is associated with rapid cancer development in rodent studies at all doses tested, a risk that is not fully understood in humans.
PCT & Support
Due to the suppression from RAD-140 and MK-2866, a SERM-based PCT is mandatory. On-cycle support for lipids is less critical due to GW’s positive effects, but liver support remains essential.
Stack Protocol
| Week | GW-501516 (Cardarine) | MK-2866 (Ostarine) | RAD-140 (Testolone) | Support & Notes |
|---|---|---|---|---|
| 1 | 10 mg/day | 15 mg/day | 10 mg/day | Baseline: Full bloodwork. Start liver support (NAC, TUDCA). Begin caloric deficit. |
| 2 | 15 mg/day | 20 mg/day | 15 mg/day | Endurance boost from GW becomes noticeable. Joints should feel better from MK. |
| 3 | 20 mg/day | 20 mg/day | 20 mg/day | Strength should remain high despite the deficit. Consider introducing low-dose SERM (e.g., Enclomiphene 6.25mg/day) if suppression symptoms appear. |
| 4 | 20 mg/day | 20 mg/day | 20 mg/day | Monitor resting heart rate (GW can increase cardiovascular output). Fat loss should be visibly accelerating. |
| 5 | 20 mg/day | 20 mg/day | 20 mg/day | Mid-Cycle Bloodwork Strongly Advised. Expect suppression. HDL may be elevated, LDL may be improved due to GW. |
| 6 | 20 mg/day | 20 mg/day | 20 mg/day | Performance in cardio sessions will be significantly enhanced. |
| 7 | 20 mg/day | 20 mg/day | 20 mg/day | Final week of anabolics (RAD & MK). Continue GW. |
| 8 | 20 mg/day | OFF | OFF | GW-only week. Aids in continuing fat loss and preserving endurance while anabolics clear. Maintain deficit. |
| PCT Start | — | — | — | Begin PCT Week 9 (See FAQ) |
Recommendations
Bloodwork is Essential
Pre, mid (week 5), and post (5-6 weeks after PCT) bloods to monitor Testosterone, LH, FSH, and liver enzymes. The lipid panel is especially interesting here to observe GW’s effects.
Liver Support
Continue NAC/TUDCA throughout the cycle and PCT. Despite GW’s benefits, RAD and MK are hepatotoxic.
Diet & Training
Maintain a moderate caloric deficit (300-500 kcal). Protein intake must be high (1.2g+/lb bodyweight) to leverage the anabolic environment. Training should be intense with a focus on strength maintenance. This stack allows for significantly increased cardio volume and performance—use it.
On-Cycle Therapy (OCT)
Having a SERM like Enclomiphene on hand is wise. Starting it at a low dose (6.25mg ED) around week 4-5 can mitigate low-T symptoms without blunting the cycle’s effects.
Lean Physique SARMs Stack Cheat Sheet
Drew –
Rad usually shuts me down hard but stacking it with Ostarine seems to help a bit. 5 stars stack